L. stimulation activates PKA, which phosphorylates MST4 at Thr-178 and then promotes MST4 kinase activity. Interestingly, activated MST4 then phosphorylates ezrin prephosphorylated by PKA. Importantly, MST4 is important for acid secretion in parietal cells because either suppression of MST4 or…

We then developed an assay to test their function. subset. Despite the absence of Foxp3 manifestation, these CD8+Foxp3?CD103+ Treg cells display an anergic phenotype and develop potent suppressive activity against T cell responses. With IL-10 and TGF- signals both contributing…