The results has been presented inTable 1

The results has been presented inTable 1. == Table 1. thrombolysis with SK (P< 0.05). Conclusion:Adhesion molecules which mediate the interactions IKK-3 Inhibitor in leukocyte endothelium vary in levels after reperfusion with SK. It was shown that 4 out of 6 adhesion molecules significantly reduced after thrombolysis with SK. Keywords:Adhesion Molecules, Myocardial Infarction, Streptokinase == Introduction == Cardiovascular disease is the most prevalent and major cause of death world wide and burdens huge costs on the health care system.1-4Mortality due to Ischemic Heart Diseases (IHD) deacreases by early treatment and long term survival in patients increases subsequently.5Coronary artery reperfusion is accepted as a method to achieve reduction in size of myocardial infarction.6Thrombolysis technique with streptokinase (SK) is a confirmed method for reopening of an occluded vessel in patients with acute myocardial infarction.6Cellular adhesion molecules (such as: P-selectin, E-selectin, L-selectin, VCAM-1, PECAM-1, ICAM-1) have an important role to play in progression of atherosclerotic plaque.7,8 Besides, those mononuclear cells which are responsible for release of matrix metalloproteinases are activated by adhesion molecules leading to plaque rupture and initiation of acute coronary syndrome. Consequently, it can be concluded that an intervention leadngs to decline in adhesion molecules level could postpone the process of atherosclerotic plaque formation or rupture. On the other hand, it has been shown that patients with high levels of these adhesion molecules IKK-3 Inhibitor have poor prognosis in future.9Some studies imply that adhesion molecules would decrease10or increase11in level, after reperfusion with different types of thrombolytic drugs. Here in our hospitals in Iran, the only cost-benefit and available thrombolytic drug for reperfusion of coronary arteries in patients with acute myocardial infarction is intravenous thrombolysis with streptokinase (SK), 1.5 million IU over 60 minutes. The aim of Rabbit Polyclonal to APBA3 this study was to compare concentrations of six soluble forms of adhesion molecules in patients with acute myocardial infarction before and 3 hour after attempted reperfusion by thrombolysis with streptokinase (SK). == Materials and Methods == From January to June 2011, 40 patients admitted to the emergency department of Rasul-Akram Hospital with the diagnosis of acute myocardial infarction (based on a history of typical chest pain and electrocardiographic changes) and with no contraindication of streptokinase administration were included in this study. The patients were selected using a convenient sampling method. Blood samples from all 40 patients were taken prior to thrombolysis with SK, and then 3 hours after treatment. Plasma samples werer extracted by centrifugation at 4C, at 3000 rpm for 10 min. Samples were later stored at 80C before measurement of plasma levels of the soluble forms sE-selectin, sL-selectin, sPselectin, sICAM-1, sVCAM-1, and sPECAM-1 using commercially available enzyme-linked immunosorbent assays (ELISAs). Results were presented as meanstandard deviation (SD) for serum levels of adhesion molecules before and after thrombolysis IKK-3 Inhibitor with SK. The Statistical test used in this study was Paired-Sample t-Test. A P 0.05 was considered statistically significant. The SPSS 17 (SPSS Inc., Chicago, Illinois, USA) statistical software package was used for all calculations. Our study was approved by the ethics committee of Iran University of Medical Sciences (IUMS). Informed written consent was obtained from each patient or his or her guardian. == Results == All 40 patients who were included in the study were in the age range of 46 to 83 years old (65.90 10.6 IKK-3 Inhibitor years). There were 30 male patients (75%) and 10 female patients (25%). The levels of 6 adhesion molecules were measured before and 3hours after thrombolysis with streptokinase (1.5 million IU over 60 min). The results has been presented inTable 1. == Table 1. Serum levels of soluble adhesion molecules. == == Discussion == Adhesion molecules are considered to be indicators of activation of leukocytes, platelets and endothelial cells. It has been shown that in patients with.