In normal subjects the VOR moves the eyes at the same speed but in the opposite direction to the head movement which is accomplished by semicircular canals projecting to the vestibular nuclei and ocular motor nuclei (15)

In normal subjects the VOR moves the eyes at the same speed but in the opposite direction to the head movement which is accomplished by semicircular canals projecting to the vestibular nuclei and ocular motor nuclei (15). In this small cohort we Gastrofensin AN 5 free base aimed to explore differences in ocular motor function between patients with anti-IGLON5 disease and PSP patients in order to support early diagnosis of anti-IGLON5 disease. velocity and accuracy, the presence of square wave jerks (SWJ) (anti-IgLON5 0/4 the lateral geniculate nucleus to the striate cortex and extrastriate areas. Further main neural areas involved in smooth pursuit vision movements are the frontal vision field, the supplemental vision field, the pontine nuclei and the cerebellum. In normal subjects the VOR moves the eyes at the same velocity but in the opposite direction to the head movement which is usually accomplished by semicircular canals projecting to the vestibular nuclei and ocular motor nuclei (15). In this small cohort we aimed to explore differences in ocular motor function between patients with anti-IGLON5 disease and PSP patients in order to support early diagnosis of anti-IGLON5 disease. The primary objective was to characterize horizontal and vertical saccadic abnormalities in the above-mentioned diseases in comparison to healthy controls (CON). Further, we spotlight differences in easy pursuit vision movements (SPEM), vestibulo-ocular reflex (VOR) function and VOR suppression. Methods We investigated quantitative VOG data of patients with anti-IgLON5 Col4a3 disease and compared them with those of patients with progressive supranuclear palsy-parkinsonism (PSP-P) or classic Richardsons syndrome (PSP-RS) and CON with normal ocular motor function (see below). VOG data of patients diagnosed with anti-IgLON5 disease between years 2015 and 2018 and of patients with PSP, diagnosed between years 2012 and 2018 have been reviewed and analyzed retrospectively. Subjects Four patients suffering from anti-IgLON5 disease and ten patients diagnosed with PSP (5 PSP-RS, 5 Gastrofensin AN 5 free base PSP-P) underwent VOG and rotational chair testing. Patients were diagnosed according to the established 2017 International Parkinsons and Movement Disorder Society (MDS) Criteria for the Diagnosis Gastrofensin AN 5 free base of PSP (7). Patients enrolled before 2017 were revisited and classified according to the recent MDS-PSP criteria for PSP-P and PSP-RS. Diagnosis of anti-IgLON5 disease was supported by the use of established criteria for autoimmune-encephalitis and confirmed by anti-IgLON5 antibody detection (1, Gastrofensin AN 5 free base 14, 16). Auto-antibodies were determined using a well-established in-house routine cell-based-assay as reported earlier (17). No other Gastrofensin AN 5 free base antibodies were found in patients with anti-IgLON5 disease, and no antibodies (including anti-IgLON5 antibodies) were found in patients with PSP. All patients underwent VOG at least once, the VOG-recording closest to time of diagnosis was used for analysis. Patients were excluded from VOG if any restrictions were present that would have limited the patients cooperation during the examination. The protocol was approved by the local ethics committee of the Medical University of Vienna (EK nr. EK 1773/2016; 1123/2015). Controls Ten sex- and age-matched subjects without history of any neurological disease and with normal neurological examination served as CON. Video-Oculography and Rotational Chair System VOG and a computer-controlled rotational chair system (System 2000, Micromedical Technologies, Illinois, USA), were used to assess ocular motor and vestibular function (sampling rate 60 Hz). The patients head was fixed in a u-shaped headrest at suboccipital height. Stimuli were applied by a laser projector. Protocol Spontaneous Eye Movements In this task the patients were instructed to fix an imaginary point on the wall for 30 seconds in complete darkness while looking straight ahead and not to move their eyes. Saccades and Square Wave Jerks For horizontal and vertical saccade testing, the target moved randomly in amplitude actions of 5 – 30 in both directions in the horizontal and vertical plane, respectively..