These results clearly demonstrate the superiority of dual HER2-directed therapy

These results clearly demonstrate the superiority of dual HER2-directed therapy. treatment of NSCLC [2]. Rabbit polyclonal to Smac Moreover, three anti-PD-1/anti-PD-L1 brokers, pembrolizumab, BI 1467335 (PXS 4728A) nivolumab and atezolizumab, have been approved for second-line therapy of NSCLC [16C18]; however, contrary to melanoma, patient selection to therapy should be based on PD-L1 expression level of tumour cells. Recent landmark trials in STS Another topic featured in this article collection is usually systemic therapy in STS [5], which is a heterogeneous group of rare solid tumours. Despite optimal local treatment, approximately 50% of adult patients with localised STS develop distant metastases and pass away of metastatic disease. A limited number of drugs have shown activity in advanced disease, and due to the rarity of these tumours, clinical trials in sarcoma include many subtypes and are mainly initiated by academic research groups. Recent developments in the classification of STS, insights into their molecular pathogenesis and the optimal treatment strategies have evolved considerably during the past decades and have led to the introduction of new therapies. Nevertheless, the selection of systemic therapy must be purely individualised and based upon several factors, including the histology and biological behaviour of the disease. A summary of recent pivotal trials for systemic therapy in advanced STS is usually presented in Table?2 [19C22]. Table 2 Summary of recent pivotal clinical trials in advanced soft tissue sarcomas value)value)overall survival; BI 1467335 (PXS 4728A) progression-free survival Recent landmark trials in breast and gynaecological cancers Recent landmark trials in HER2-positive breast cancer include those using dual HER2-targeted therapy pertuzumab and trastuzumab with docetaxel. In the neoadjuvant setting, the NeoSphere trial exhibited significantly improved pathological total response rates [23] and a pattern favouring improved PFS and OS at 5?years [24]. Results from the CLEOPATRA trial in the metastatic setting of the same treatment have produced remarkable results [25]; the same combination produced a 56.5-month median OS compared with 40.8?months achieved with trastuzumab and docetaxel alone, showing an increase of 15.7?months to OS in the pertuzumab group. These results clearly demonstrate the superiority of dual HER2-directed therapy. In ER-positive, HER2-unfavorable metastatic disease, the landmark trial (PALOMA 3) uses the CDK 4/6 inhibitor, palbociclib [26, 27]. Median PFS was 9.5?months in the fulvestrant plus palbociclib group and 4.6?months in the fulvestrant plus placebo group with a hazard ratio of 0.46, which was highly statistically significant. However, translational research did not discover any predictive biomarker subgroups [27] for the palbociclib effect. The landmark phase III BI 1467335 (PXS 4728A) trials in high-grade serous ovarian malignancy are screening PARP inhibitors as maintenance therapy after response to platinum-based therapy in relapsed disease. Study 19 [28, 29] used olaparib against placebo and exhibited a PFS of 11.2?months in cohort; 12.9 vs. 3.8?months in the non-gcohort for patients who also had tumours with homologous recombination deficiency; and 9.3 vs. 3.9?months in the overall non-gcohort; series BI 1467335 (PXS 4728A) Spotlight on landmark oncology trials and this editorial are recent trials that have produced practice-changing results for patients. These trials represent the end of the long process of translating scientific development and drug discovery, through first-in-man studies, followed by phase II trials and finally by randomised phase III trials as required for licensing of new treatments. Novel trial designs could potentially lead to a different type of landmark trial that would accelerate the process and allow malignancy patients to access new treatments faster. In the phase I setting, there is a pressing need to develop better trial methodologies for novel combinations, often of a standard chemotherapy with a novel targeted agent. Di Veroli et al. [39] published an interesting software to provide information in terms of synergy and/or antagonism.